Monday, September 1, 2025
Young Scientist Meeting with Coffee Break |
2.00 pm-6.00 pm
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Welcome words from Yasmine Belkaid, General manager of Institut Pasteur |
6.00 pm-6.15 pm
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Opening Keynote |
6.15 pm-7.15 pm
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6.15 pm |
New perspectives onClostridioides difficile infection: host dynamics and disease risk
Dena Lyras Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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''Aperitif'' and Early Welcome Dinner |
7.15 pm-9.00 pm
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Tuesday, September 2, 2025
Session 1: One Health |
09.00 am-10.30 am
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09.00 am |
Maja Rupnik University of Maribor
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09.30 am |
Botulism outbreaks in livestock and wildlife: Assessing public health risks through a One Health approach
Caroline Le Maréchal Unité HQPAP, Laboratory of Ploufragan-Plouzané-Niort, ANSES, Ploufragan, France
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09.50 am |
Comparing the severity of Clostridium perfringens-induced gas gangrene in normal vs. diabetic mice
Francisco Uzal University of California-Davis, San Bernardino, United States
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10.10 am |
Potency test of the first commercial vaccine for prevention of Clostridioides difficile infection in piglets
Rodrigo Otávio Silva Federal University of Minas Gerais (Brasil), Belo Horizonte, Brazil
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Coffee Break |
10.30 am-11.00 am
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Session 2: Microbiota |
11.00 am-1.00 pm
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11.00 am |
Marina Munoz Columbia, United States
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11.30 am |
Enterococcus faecalis alters phase variation in Clostridioides difficile
Ashley Weiss Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, United States
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11.50 am |
A sugar-rich diet promotes Clostridioides difficile carriage without prior antibiotics and significantly exacerbates both acute disease and long-term colonization.
Daniel Erickson Microbiology & Immunology, University of Louisville, Louisville, United States
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12.10 pm |
Bacteroides spp impact Clostridioides difficile growth and toxin production in dual species biofilms
Meera Unnikrishnan Warwick Medical School, University of Warwick, Coventry, United Kingdom
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12.30 pm |
Raymond Kiu United Kingdom
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Session 3: Phage & surface |
2.30 pm-4.30 pm
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2.30 pm |
Controlling Phage–Host Dynamics: Safeguarding Beneficial Bacteria and Targeting Pathogens
Louis-Charles Fortier Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada
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3.00 pm |
PSII, S-layer pillars is essential for Clostridioides difficile life
Léa Huet BaPS, Institut Micalis, Université Paris-Saclay, INRAE, AgroParisTech, Jouy-En-Josas, France
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3.20 pm |
Dissecting the biosynthetic pathway of the flagellin Type A glycan in Clostridioides difficile strain 630Δerm
Paul Hensbergen Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
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3.40 pm |
Extreme structural diversification of the C. difficile S-layer exoskeletons
Anna Barwinska-Sendra Medical School, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom
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4.00 pm |
An unusual mechanism of action of β-lactam antibiotics in Clostridioides difficile
Johann Peltier Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-Sur-Yvette, France
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Coffee Break |
4.30 pm-5.00 pm
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Posters Session |
5.00 pm-7.00 pm
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Dinner on your own |
7.00 pm-10.00 pm
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Wednesday, September 3, 2025
Session 4: Toxins |
09.00 am-11.05 am
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09.00 am |
Botulinum Neurotoxins: A Distinct Subclass of SNARE-CleavingEndopeptidases
Sabine Pellett University of Wisconsin, Department of Bacteriology, Madison, United States
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09.30 am |
Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47
Rongsheng Jin School of Medicine, University of California, Irvine, Irvine, United States
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09.50 am |
Structural basis of C. difficile TcdB toxin inhibition by intestinal bile acids informs design of a therapeutic antitoxin
Roman Melnyk University of Toronto, Toronto, Canada
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10.10 am |
Clostridial hemolysin beta-pore-forming toxins find their receptors
Jan Franzen Department of Infectious Diseases and Pathobiology, Institute of Animal Pathology, Posthaus Lab, University of Bern, Bern, Switzerland Graduate School for Cellular and Biomedical Sciences, Bern, Switzerland
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10.45 am |
Intestinal low dose of botulinum neurotoxins facilitate infection by Salmonella and Shigella
Ornella Rossetto Biomedical Sciences, University of Padova, Padova, Italy Institute of Neuroscience, National Research Council, Padova, Italy
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Coffee Break |
11.05 am-11.35 am
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Session 5: Host response to infection |
11.35 am-1.25 pm
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11.35 am |
Type 2 Immunity Protection fromC. difficile Infection
William Petri University of Virginia, Charlottesville, United States
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12.05 pm |
Spatial transcriptomic landscape of the colon repairing from Clostridioides difficile infection
Ashleigh Rogers Department of Microbiology, Monash University, Clayton, Australia Infection and Immunity Program, Monash University, Clayton, Australia
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12.25 pm |
An in vivo genetic selection identifies Clostridioides difficile gene products targeted by the host immune response
Sarah Price Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, United States
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12.45 pm |
Potentially therapeutic antibodies are encoded by the C. difficile infection-induced human memory B cell compartment despite the predominance of non-protective antibodies
Sydney Honold University of Oklahoma Health Sciences Center, Oklahoma City, United States
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1.05 pm |
FMT promotes type 2 mucosal immune responses with colonic epithelium proliferation in recurrent CDI patients
G. Brett Moreau Infectious Diseases and International Health, University of Virginia, Charlottesville, United States
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Planned Activities / Free time / Dinner on your own |
3.00 pm-11.00 pm
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Thursday, September 4, 2025
Memorial |
09.00 am-09.15 am
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Session 6: Regulation |
09.15 am-10.45 am
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09.15 am |
The complex regulatory network controlling Clostridioides difficile infectious cycle in response to oxidative stress
Isabelle Martin-Verstraete Institut Pasteur, Université Paris Cité, UMR CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, Paris, France
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09.45 am |
Cracking the Mechanism of EndoM: How It Degrades Small RNA and Controls Sporulation Initiation in Clostridioides difficile
Diogo Martins ITQB NOVA, Oeiras, Portugal
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10.05 am |
Flagella and toxins reduce Clostridioides difficile fitness in an inflammation-dependent manner
Nicole Gadda Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, United States
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10.25 am |
BrnQ branched-chain amino acid transporters affect toxin production of Clostridium perfringens gas gangrene type A strain ATCC3624
Jihong Li Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, United States
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Coffee Break |
10.45 am-11.15 am
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Session 7: Physiology |
11.15 am-12.45 pm
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11.15 am |
A Conserved Switch Controls Virulence, Sporulation, and Motility in C. difficile
Shonna McBride Department of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, United States
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11.45 am |
Surface-driven physiological adaptations promote Clostridioides difficile colonization
Po-Long Hsiao Institute of Bioengineering and Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
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12.05 pm |
90 years of Stickland reaction: How clostridial amino acid reductases obtain their pyruvoyl cofactor
Wulf Blankenfeldt Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany
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12.25 pm |
Gut mucin fucosylation dictates the entry of botulinum toxin complexes
Takuhiro Matsumura Department of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
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Lunch & Poster Session |
12.45 pm-3.00 pm
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Session 8: Spore |
3.00 pm-4.30 pm
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3.00 pm |
Spores in Contrast: Stereoflexible and Bile-Driven Germination in Clostridium
Ian Cheong Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore
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3.30 pm |
Inter-species contact-dependent suppression of Clostridioides difficile sporulation requires Enterococcus pili
Peter Mckenney Binghamton University, Binghamton, United States
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3.50 pm |
A plasmid-encoded protein modulates sporulation in Paraclostridium sordellii
Sarah Revitt-Mills Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia
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4.10 pm |
Strand swapping in the LolA-like protein GerS promotes CwlD amidase activity and spore germination in Clostridioides difficile
Jacob Bouchier Molecular Biology and Microbiology, Tufts University, Boston, United States
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Coffee Break |
4.30 pm-4.45 pm
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Session 9: Clinical |
4.45 pm-6.25 pm
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4.45 pm |
Kevin Garey Houston, United States
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5.15 pm |
Molecular and cellular basis of Clostridium perfringens epsilon toxin mediated oligodendrocyte injury and central nervous system demyelination
Timothy Vartanian Brain and Mind Research Institute, Weill Cornell Medical College, Cornell University, New York, United States
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5.45 pm |
Mucosal vaccination of inactivated Clostridioides difficile toxins and novel surface antigens clears colonization and promotes host survival
Audrey Thomas Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center, Nashville, United States Microbe-Host Interactions PhD Program, Vanderbilt University, Nashville, United States
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6.05 pm |
An overview of C difficile infection incidence around the world, with a focus on France
Jennifer Moisi Pfizer
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Congress Dinner |
7.00 pm-10.00 pm
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