Programme
ClostPath 2025
September 1-4, 2025
Institut Pasteur, Paris, France
 
Monday, September 1, 2025
Young Scientist Meeting with Coffee Break
2.00 pm-6.00 pm
Welcome words from Yasmine Belkaid, General manager of Institut Pasteur
6.00 pm-6.15 pm
Opening Keynote
6.15 pm-7.15 pm
0
6.15 pm

New perspectives onClostridioides difficile infection: host dynamics and disease risk

Dena Lyras
Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
''Aperitif'' and Early Welcome Dinner
7.15 pm-9.00 pm
Tuesday, September 2, 2025
Session 1: One Health
09.00 am-10.30 am
0
09.00 am
Maja Rupnik
University of Maribor
0
09.30 am

Botulism outbreaks in livestock and wildlife: Assessing public health risks through a One Health approach

Caroline Le Maréchal
Unité HQPAP, Laboratory of Ploufragan-Plouzané-Niort, ANSES, Ploufragan, France
0
09.50 am

Comparing the severity of Clostridium perfringens-induced gas gangrene in normal vs. diabetic mice

Francisco Uzal
University of California-Davis, San Bernardino, United States
0
10.10 am

Potency test of the first commercial vaccine for prevention of Clostridioides difficile infection in piglets

Rodrigo Otávio Silva
Federal University of Minas Gerais (Brasil), Belo Horizonte, Brazil
Coffee Break
10.30 am-11.00 am
Session 2: Microbiota
11.00 am-1.00 pm
0
11.00 am
Marina Munoz
Columbia, United States
0
11.30 am

Enterococcus faecalis alters phase variation in Clostridioides difficile

Ashley Weiss
Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, United States
0
11.50 am

A sugar-rich diet promotes Clostridioides difficile carriage without prior antibiotics and significantly exacerbates both acute disease and long-term colonization.

Daniel Erickson
Microbiology & Immunology, University of Louisville, Louisville, United States
0
12.10 pm

Bacteroides spp impact Clostridioides difficile growth and toxin production in dual species biofilms

 

Meera Unnikrishnan
Warwick Medical School, University of Warwick, Coventry, United Kingdom
0
12.30 pm
Raymond Kiu
United Kingdom
Lunch
1.00 pm-2.30 pm
Session 3: Phage & surface
2.30 pm-4.30 pm
0
2.30 pm

Controlling Phage–Host Dynamics: Safeguarding Beneficial Bacteria and Targeting Pathogens

Louis-Charles Fortier
Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada
0
3.00 pm

PSII, S-layer pillars is essential for Clostridioides difficile life

Léa Huet
BaPS, Institut Micalis, Université Paris-Saclay, INRAE, AgroParisTech, Jouy-En-Josas, France
0
3.20 pm

Dissecting the biosynthetic pathway of the flagellin Type A glycan in Clostridioides difficile strain 630Δerm

Paul Hensbergen
Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
0
3.40 pm

Extreme structural diversification of the C. difficile S-layer exoskeletons

Anna Barwinska-Sendra
Medical School, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom
0
4.00 pm

An unusual mechanism of action of β-lactam antibiotics in Clostridioides difficile

Johann Peltier
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-Sur-Yvette, France
Coffee Break
4.30 pm-5.00 pm
Posters Session
5.00 pm-7.00 pm
Dinner on your own
7.00 pm-10.00 pm
Wednesday, September 3, 2025
Session 4: Toxins
09.00 am-11.05 am
0
09.00 am

Botulinum Neurotoxins: A Distinct Subclass of SNARE-CleavingEndopeptidases

Sabine Pellett
University of Wisconsin, Department of Bacteriology, Madison, United States
0
09.30 am

Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47

Rongsheng Jin
School of Medicine, University of California, Irvine, Irvine, United States
0
09.50 am

Structural basis of C. difficile TcdB toxin inhibition by intestinal bile acids informs design of a therapeutic antitoxin

Roman Melnyk
University of Toronto, Toronto, Canada
0
10.10 am

Clostridial hemolysin beta-pore-forming toxins find their receptors

Jan Franzen
Department of Infectious Diseases and Pathobiology, Institute of Animal Pathology, Posthaus Lab, University of Bern, Bern, Switzerland Graduate School for Cellular and Biomedical Sciences, Bern, Switzerland
0
10.45 am

Intestinal low dose of botulinum neurotoxins facilitate infection by Salmonella and Shigella

Ornella Rossetto
Biomedical Sciences, University of Padova, Padova, Italy Institute of Neuroscience, National Research Council, Padova, Italy
Coffee Break
11.05 am-11.35 am
Session 5: Host response to infection
11.35 am-1.25 pm
0
11.35 am

Type 2 Immunity Protection fromC. difficile Infection

William Petri
University of Virginia, Charlottesville, United States
0
12.05 pm

Spatial transcriptomic landscape of the colon repairing from Clostridioides difficile infection

Ashleigh Rogers
Department of Microbiology, Monash University, Clayton, Australia Infection and Immunity Program, Monash University, Clayton, Australia
0
12.25 pm

An in vivo genetic selection identifies Clostridioides difficile gene products targeted by the host immune response

Sarah Price
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, United States
0
12.45 pm

Potentially therapeutic antibodies are encoded by the C. difficile infection-induced human memory B cell compartment despite the predominance of non-protective antibodies

Sydney Honold
University of Oklahoma Health Sciences Center, Oklahoma City, United States
0
1.05 pm

FMT promotes type 2 mucosal immune responses with colonic epithelium proliferation in recurrent CDI patients

G. Brett Moreau
Infectious Diseases and International Health, University of Virginia, Charlottesville, United States
Lunch
1.25 pm-3.00 pm
Planned Activities / Free time / Dinner on your own
3.00 pm-11.00 pm
Thursday, September 4, 2025
Memorial
09.00 am-09.15 am
Session 6: Regulation
09.15 am-10.45 am
0
09.15 am

The complex regulatory network controlling Clostridioides difficile infectious cycle in response to oxidative stress

Isabelle Martin-Verstraete
Institut Pasteur, Université Paris Cité, UMR CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, Paris, France
0
09.45 am

Cracking the Mechanism of EndoM: How It Degrades Small RNA and Controls Sporulation Initiation in Clostridioides difficile

Diogo Martins
ITQB NOVA, Oeiras, Portugal
0
10.05 am

Flagella and toxins reduce Clostridioides difficile fitness in an inflammation-dependent manner

Nicole Gadda
Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, United States
0
10.25 am

BrnQ branched-chain amino acid transporters affect toxin production of Clostridium perfringens gas gangrene type A strain ATCC3624

Jihong Li
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, United States
Coffee Break
10.45 am-11.15 am
Session 7: Physiology
11.15 am-12.45 pm
0
11.15 am

A Conserved Switch Controls Virulence, Sporulation, and Motility in C. difficile

Shonna McBride
Department of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, United States
0
11.45 am

Surface-driven physiological adaptations promote Clostridioides difficile colonization

Po-Long Hsiao
Institute of Bioengineering and Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
0
12.05 pm

90 years of Stickland reaction: How clostridial amino acid reductases obtain their pyruvoyl cofactor

Wulf Blankenfeldt
Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany
0
12.25 pm

Gut mucin fucosylation dictates the entry of botulinum toxin complexes

Takuhiro Matsumura
Department of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
Lunch & Poster Session
12.45 pm-3.00 pm
Session 8: Spore
3.00 pm-4.30 pm
0
3.00 pm

Spores in Contrast: Stereoflexible and Bile-Driven Germination in Clostridium

Ian Cheong
Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore
0
3.30 pm

Inter-species contact-dependent suppression of Clostridioides difficile sporulation requires Enterococcus pili

Peter Mckenney
Binghamton University, Binghamton, United States
0
3.50 pm

A plasmid-encoded protein modulates sporulation in Paraclostridium sordellii

Sarah Revitt-Mills
Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia
0
4.10 pm

Strand swapping in the LolA-like protein GerS promotes CwlD amidase activity and spore germination in Clostridioides difficile

Jacob Bouchier
Molecular Biology and Microbiology, Tufts University, Boston, United States
Coffee Break
4.30 pm-4.45 pm
Session 9: Clinical
4.45 pm-6.25 pm
0
4.45 pm
Kevin Garey
Houston, United States
0
5.15 pm

Molecular and cellular basis of Clostridium perfringens epsilon toxin mediated oligodendrocyte injury and central nervous system demyelination

Timothy Vartanian
Brain and Mind Research Institute, Weill Cornell Medical College, Cornell University, New York, United States
0
5.45 pm

Mucosal vaccination of inactivated Clostridioides difficile toxins and novel surface antigens clears colonization and promotes host survival

Audrey Thomas
Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center, Nashville, United States Microbe-Host Interactions PhD Program, Vanderbilt University, Nashville, United States
0
6.05 pm

An overview of C difficile infection incidence around the world, with a focus on France

Jennifer Moisi
Pfizer
Congress Dinner
7.00 pm-10.00 pm


 

 

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